Is It Necessary To Conduct Subchronic Toxicity Test For Dental Noble-metal Alloys?

The toxicity, allergic reaction and other adverse biological reactions of dental alloys to human bodies are closely related to metal elements released into the oral cavity. The degree of biological reaction of dental alloys is affected by the nature and concentration of elements released as well as the duration of exposure to oral tissues. It is recommended to consider the biocompatibility of dental noble-metal alloys from the following aspects:

1. The quantity, type, microstructure and composition of phases in alloy;
2. Whether there are such elements as copper, zinc, silver, calcium and nickel;
3. Single metal elements may be greater than alloyed metal elements;
4. Various combinations of alloy elements in the oral cavity may change the corrosion and biocompatibility of alloys;
5. Whether the element release level of alloy containing noble metal elements is lower than that of ordinary alloys.